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Glossary of Words

 

Allogeneic  from a donor other than
yourself and other than a
syngeneic twin
   
Autologous from yourself; your own
   
Autoimmune disease disease induced by a situation in which your immune system develops markers (antigens) against cells of your tissues or organs
   
Bone marrow abnormality aplasia, myeloadysplasia
   
Chemotherapy drugs that induce cell death
   
Clinical research the science of development, implementation and execution of clinical studies, and the analysis and reporting of study results
   
Clinical study an examination of the safety, efficacy and effectiveness of a product or treatment strategy according to a written protocol
   
Clinical trial an effort to try to evaluate the effect of a product or treatment strategy according to a written protocol
   
Combined modality a combination of compounds, products or strategies used together as one treatment within a predefined time frame; for example, chemotherapy combined with autologous and/or allogeneic reduced intensity conditioning stem cell transplant
   
Cord Blood blood retrieved from umbilical cords
   
Cytotoxic toxic to cells; induction of cell death
   
Disseminated distantly spread out; metastatic
   
Donor a person who donates stem cells; you can be your own donor (autologous) or someone else donates stem cells to you for infusion (allogeneic)
   
Dose-reduced transplant reduced intensity conditioning transplant; the preparative regimen (chemotherapy) does not ablate marow; that means, that marrow could recover, also without infusion of stem cells, but only after a long time
   
Effectiveness refers to the safety, efficacy and cost-efficiency of a treatment; that means it is an indication for the effect of the treatment on long-term outcome of the disease
   
Efficacy degree to which a treatment is able to induce a response to the treatment
   
Eligibility describes the criteria that need to be fulfilled to participate in a study; these may involve demographics, disease and disease stage, your condition, prior treatment, etc.
   
G-CSF granulocyte colony-stimulating factor; a compound that induces proliferation of granulocytes
   
Graft-versus-host-disease a situation in which donor lymphocytes attack normal host cells
   
Graft-versus-leukemia a situation in which donor lymphocytes attack leukemia
   
Graft-versus-tumor a situation in which donor lymphocytes attack tumor cells
   
Granulocytes subset of  white blood cells that protect against infection, are involved in wound healing, etc.
   
Good Clinical Practice guidelines defined by an international organization according to which treatment should be performed when you are enrolled in a clinical study
   
Harvest collection
   
Hematological malignancies Acute leukemia, chronic leukemia, plasma cell cancer or Kahler's disease; lymphoma are sometimes counted  to hematological cancer
   
Hematopoietic blood cell producing
   
HLA-typing examination of histocompatibility leukocyte antigens; important procedure for finding an allogeneic donor
   
Hodgkin's disease lymph node cancer
   
Immune competent able to induce an immune response; a lymphocyte is an immune competent cell
   
Immune therapy therapy with biologic agents or cells that can elicit an immune response or produce immune markers
   
Informed consent document to be signed by the patient and members of a treatment team that explains the treatment, the study procedures, site effects, benefits and risks to be expected from the treatment
   
Leukapheresis procedure by which white cells are collected from the blood of a donor by a machine called apheresis machine
   
Leukemia cancer of white bone marrow cells; they may circulate in the blood as white blood cells
   
Lymphocytes subset of white blood cells that elicit and are involved in an immune response
   
Lymphoma term for non-Hodgkin lymphoma and/or Hodgkin's disease
   
Lymph node cancer Lymphoma
   
Malignant disease another term for cancer or cancerous tumor
   
Mini-transplant another name for reduced intensity conditioning transplant
   
Monocytes subset of white blood cells that clear pathogens and damaged cells from the blood stream and tissues
   
Multiple myeloma Disease of Kahler; cancer of plasma cells; plasma cells are bone marrow stem cells that produce immunoglobulines
   
Myeloablative eradication of all stem cells from the bone marrow such that bone marrow recovery could not occur without infusion of stem cells
   
Neuroblastoma embryonic neural cell cancer
   
Non-hodgkin lymphoma cancer of lymphocytes in- and outside lymph nodes
   
Non-myeloablative reduction of  the stem cell content of the bone marrow to a degree that  some recovery might occur without infusion of stem cells
   
Peripheral blood progenitor cells bone marrow cells mobilized into the blood 
   
Preparative regimen chemotherapy and/or radiotherapy administered as part of the transplant procedure
   
Protocol document that describes all aspects of the treatment of a clinical study
   
Recurrence disease relapse; the disease comes back after complete remission or complete response
   
Relapse disease recurrence; the disease comes back after   complete remission or complete response
   
Safety refers to the degree of side effects caused by a treatment; if few side effects are induced the treatment is safe; if many of severe side effects are induced the treatment may be unsafe
   
Stem cell undifferentiated cell that can proliferate indefinitely without dying
   
Stem cell transplant strictly, the infusion of stem cells; broadly, the total   procedure of chemotherapy prior to transplant plus infusion of stem cells
   
Solid tumors Cancers in which cells clup together
   
Transplanter doctor who can administer a stem cell transplant
   
Vene blood vessel of the venous system, which is the blood vessel system that carries blood to your heart

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