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Glossary of Words


Allogeneic  from a donor other than
yourself and other than a
syngeneic twin
Autologous from yourself; your own
Autoimmune disease disease induced by a situation in which your immune system develops markers (antigens) against cells of your tissues or organs
Bone marrow abnormality aplasia, myeloadysplasia
Chemotherapy drugs that induce cell death
Clinical research the science of development, implementation and execution of clinical studies, and the analysis and reporting of study results
Clinical study an examination of the safety, efficacy and effectiveness of a product or treatment strategy according to a written protocol
Clinical trial an effort to try to evaluate the effect of a product or treatment strategy according to a written protocol
Combined modality a combination of compounds, products or strategies used together as one treatment within a predefined time frame; for example, chemotherapy combined with autologous and/or allogeneic reduced intensity conditioning stem cell transplant
Cord Blood blood retrieved from umbilical cords
Cytotoxic toxic to cells; induction of cell death
Disseminated distantly spread out; metastatic
Donor a person who donates stem cells; you can be your own donor (autologous) or someone else donates stem cells to you for infusion (allogeneic)
Dose-reduced transplant reduced intensity conditioning transplant; the preparative regimen (chemotherapy) does not ablate marow; that means, that marrow could recover, also without infusion of stem cells, but only after a long time
Effectiveness refers to the safety, efficacy and cost-efficiency of a treatment; that means it is an indication for the effect of the treatment on long-term outcome of the disease
Efficacy degree to which a treatment is able to induce a response to the treatment
Eligibility describes the criteria that need to be fulfilled to participate in a study; these may involve demographics, disease and disease stage, your condition, prior treatment, etc.
G-CSF granulocyte colony-stimulating factor; a compound that induces proliferation of granulocytes
Graft-versus-host-disease a situation in which donor lymphocytes attack normal host cells
Graft-versus-leukemia a situation in which donor lymphocytes attack leukemia
Graft-versus-tumor a situation in which donor lymphocytes attack tumor cells
Granulocytes subset of  white blood cells that protect against infection, are involved in wound healing, etc.
Good Clinical Practice guidelines defined by an international organization according to which treatment should be performed when you are enrolled in a clinical study
Harvest collection
Hematological malignancies Acute leukemia, chronic leukemia, plasma cell cancer or Kahler's disease; lymphoma are sometimes counted  to hematological cancer
Hematopoietic blood cell producing
HLA-typing examination of histocompatibility leukocyte antigens; important procedure for finding an allogeneic donor
Hodgkin's disease lymph node cancer
Immune competent able to induce an immune response; a lymphocyte is an immune competent cell
Immune therapy therapy with biologic agents or cells that can elicit an immune response or produce immune markers
Informed consent document to be signed by the patient and members of a treatment team that explains the treatment, the study procedures, site effects, benefits and risks to be expected from the treatment
Leukapheresis procedure by which white cells are collected from the blood of a donor by a machine called apheresis machine
Leukemia cancer of white bone marrow cells; they may circulate in the blood as white blood cells
Lymphocytes subset of white blood cells that elicit and are involved in an immune response
Lymphoma term for non-Hodgkin lymphoma and/or Hodgkin's disease
Lymph node cancer Lymphoma
Malignant disease another term for cancer or cancerous tumor
Mini-transplant another name for reduced intensity conditioning transplant
Monocytes subset of white blood cells that clear pathogens and damaged cells from the blood stream and tissues
Multiple myeloma Disease of Kahler; cancer of plasma cells; plasma cells are bone marrow stem cells that produce immunoglobulines
Myeloablative eradication of all stem cells from the bone marrow such that bone marrow recovery could not occur without infusion of stem cells
Neuroblastoma embryonic neural cell cancer
Non-hodgkin lymphoma cancer of lymphocytes in- and outside lymph nodes
Non-myeloablative reduction of  the stem cell content of the bone marrow to a degree that  some recovery might occur without infusion of stem cells
Peripheral blood progenitor cells bone marrow cells mobilized into the blood 
Preparative regimen chemotherapy and/or radiotherapy administered as part of the transplant procedure
Protocol document that describes all aspects of the treatment of a clinical study
Recurrence disease relapse; the disease comes back after complete remission or complete response
Relapse disease recurrence; the disease comes back after   complete remission or complete response
Safety refers to the degree of side effects caused by a treatment; if few side effects are induced the treatment is safe; if many of severe side effects are induced the treatment may be unsafe
Stem cell undifferentiated cell that can proliferate indefinitely without dying
Stem cell transplant strictly, the infusion of stem cells; broadly, the total   procedure of chemotherapy prior to transplant plus infusion of stem cells
Solid tumors Cancers in which cells clup together
Transplanter doctor who can administer a stem cell transplant
Vene blood vessel of the venous system, which is the blood vessel system that carries blood to your heart

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