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Reduced Intensity Conditioning Transplant Program 

For information about Transplant Creations program started in 2000 review this page.

We are currently raising funds for Cure for Multiple Myeloma, click here to learn more and participate in a webinar.

Protocols to treat according to our program and method described hereunder can be requested. Your doctor can contact us.

If you were recently diagnosed with leukemia, lymphoma, myeloma,  neuroblastoma or breast cancer and you wish advice whether your disease may benefit from treatment by semi-high-dose autologous (form yourself) and/or reduced intensity conditioning allogeneic (from a donor) bone marrow or peripheral blood progenitor cell transplantation as part of initial therapy you can review this page or contact us with your question. Inclusion of transplantation in your initial treatment may improve your disease outcome.

Semi high dose autologous and reduced intensity conditioning allogeneic transplants integrated in the initial therapy for early stage disease

General treatment description
The general principle of treatment is to optimize disease outcome during the initial therapy. Initial treatment takes various months. First your receive response induction chemotherapy, subsequently two semi-high dose autologous transplants and thereafter, if applicable, a reduced intensity conditioning transplant.
During response induction chemotherapy your stem cells are collected. To collect stem cells growth factor (G-CSF) or a combination of growth factors may be administered.
In multiple myeloma mobilization of stem cells is often conducted after response induction chemotherapy. Whether this is the appropriate method or whether you could receive chemotherapy and growth factor during induction treatment should be discussed with your doctor.
In patients who receive an (additional) allogeneic reduced intensity conditioning transplant, stem cells are collected from the donor. For donors treatment with G-CSF to collect stem cells is a safe procedure.
Radiotherapy is administered on indication.

Minimal Inclusion Criteria 

Patient Characteristics 
     Women or men
     Age < 60-(65) years
    
Fully active or slightly restricted in strenuous activity but ambulatory and able to carry out work

Disease Characteristics
   
First line  

    
Acute myeloid and lymphoblastic leukemia (stem cells are generally collected after you are in complete remission in the case an autologous transplant is used; alternatively you only receive an allogeneic transplant after induction and consolidation chemotherapy)
    
Stage I-III multiple myeloma
    
Chronic myeloid leukemia <12 months from diagnosis (an autologous transplant is rarely administered and a reduced intensity conditioning allogeneic transplant is generally administered after treatment with TKI, which may be administered for more than 12 months)
    
Stage IV poor risk Hodgkin's disease and intermediate and high grade non-Hodgkin's lymphoma
     Stage III (adjuvant) and IV (metastatic) breast cancer  
     Intermediate and high-risk neuroblastoma  
First relapsed   
    
Hodgkin's disease and non-Hodgkin lymphoma
Second relapsed
     Hodgkin's disease

Patients who are initially not seen by a transplanter at diagnosis, should ask the oncologist/hematologist to  refer them, such that a joint treatment plan can be developed.

Donor search
The search for a donor starts at diagnosis or at initial treatment by the oncologist or hematologist (this is the reason why you need to see a transplanter as well). Finding a donor may take one to several months. In general first a family or HLA-identical sibling donor is sought. If no HLA-identical sibling donor can be found an unrelated donor search is started to find a matched unrelated donor.
Our protocols donot permit use of mismatched donors.

Become a donor
There is always a need for bone marrow or peripheral blood progenitor cell donors. If you are young or middle aged and healthy you might be an excellent donor. Contact the donor registry in your country for information.

Reduced intensity conditioning transplants at first relapse
This treatment might be an option in case initially no donor can be found.

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