Reduced Intensity Conditioning Transplant Program
For information about Transplant Creations program started in 2000
review this page.
We are currently raising funds for Cure for
Multiple Myeloma, click
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Protocols to treat according to our program and method
described hereunder can be requested. Your doctor can
If you were recently diagnosed with
leukemia, lymphoma, myeloma, neuroblastoma or breast cancer and you
wish advice whether your
disease may benefit from treatment by semi-high-dose autologous
(form yourself) and/or reduced intensity conditioning allogeneic (from
a donor) bone marrow
or peripheral blood progenitor cell transplantation as part of initial therapy you can review this page
or contact us with your question.
Inclusion of transplantation in your initial treatment may improve
your disease outcome.
Semi high dose autologous and
reduced intensity conditioning
integrated in the initial therapy for early stage disease
The general principle
of treatment is to optimize
disease outcome during the initial therapy. Initial treatment takes
various months. First your receive response induction chemotherapy,
subsequently two semi-high dose autologous transplants and
thereafter, if applicable, a reduced intensity conditioning
During response induction chemotherapy your stem cells are
collected. To collect stem cells growth factor (G-CSF) or a
combination of growth factors may be administered.
In multiple myeloma mobilization of stem cells is often conducted
after response induction chemotherapy. Whether this is the
appropriate method or whether you could receive chemotherapy and
growth factor during induction treatment should be discussed with
In patients who receive an (additional) allogeneic reduced intensity
conditioning transplant, stem cells are collected from the donor.
For donors treatment with G-CSF to collect stem cells is a safe
Radiotherapy is administered on indication.
Minimal Inclusion Criteria
Women or men
Age < 60-(65) years
Fully active or slightly restricted in strenuous activity but
ambulatory and able to carry out work
Acute myeloid and lymphoblastic leukemia
(stem cells are generally collected after you are in complete
remission in the case an autologous transplant is used;
alternatively you only receive an allogeneic transplant after
induction and consolidation chemotherapy)
Stage I-III multiple myeloma
myeloid leukemia <12 months from diagnosis
(an autologous transplant is
rarely administered and a reduced intensity conditioning allogeneic
transplant is generally administered after treatment with TKI, which
may be administered for more than 12 months)
Stage IV poor risk Hodgkin's disease and intermediate and high grade
Stage III (adjuvant) and IV (metastatic) breast cancer
Intermediate and high-risk neuroblastoma
Hodgkin's disease and non-Hodgkin lymphoma
Patients who are initially not seen by a transplanter at diagnosis, should ask
the oncologist/hematologist to refer them, such that a joint
treatment plan can be developed.
The search for a donor starts at diagnosis or at initial treatment by the oncologist or
hematologist (this is the reason why you need to see a transplanter
as well). Finding a donor may take one to several months. In general
first a family or HLA-identical sibling donor is sought. If no HLA-identical sibling donor
can be found an unrelated donor search is started to find a matched
Our protocols donot permit use of mismatched donors.
Become a donor
There is always a need for bone marrow or
peripheral blood progenitor cell donors. If you are young or middle
aged and healthy you might be an excellent donor.
donor registry in your country for
Reduced intensity conditioning transplants
at first relapse
This treatment might be an option in case initially no donor
can be found.