Cell Transplantation for Cancer
section informs in general about blood and marrow (stem) cell transplantation for
bone marrow and blood cell cancer and organ cancer.
types of cancer can be treated by transplantation?
Several types of
cancer can be treated by blood and marrow (stem) cell transplantation.
The include among others:
myelogenous leukemia (AML)
lymphoblastic/lymphocytic leukemia (ALL)
myelogenous leukemia (CML)
lymphocytic leukemia (CLL)
- Ovarian cancer
neural cell cancer
effect does transplantation have on cancer?
The goal of treatment for cancer is to kill cancer cells and eradicate
the disease. Treatments for cancer should try to achieve that goal. Two
mechanisms appear to be very effective when applied to destroy cancer
cells receptive for these mechanisms:
Stem cell transplantation offers the opportunity to utilize both mechanisms
effectively by integration of the mechanisms in one treatment
strategy. Chemotherapy is cytotoxic; this means that chemotherapy
interferes with cancer cell proliferation and induces cancer cell
death. Immune therapy is the overall term for a variety of treatments
that elicit an effect mediated by the immune system. Immune competent
cells (lymphocytes) are one of the components of the immune system.
They have the capability to attack abnormal cells, such as foreign
cells and cancer cells. Lymphocytes are among the white blood cells
collected during a bone marrow harvest or leukapheresis. They attack
cancer cells after allogeneic transplantation and contribute
substantially to eradication of cancer cells. Logical combination of
these therapy mechanisms provides a powerful treatment option with
curative potential. Transplant Creations' clinical
research program is
designed according to such principle.
Which treatment is
The general principle is to achieve complete remission and to
administer an allogeneic transplant in complete remission to induce
the curative immune response.
Treatment modalities used to achieve complete remission include combination chemotherapy
and autologous transplantation. The risk of
disease recurrence is much higher if the disease is not in complete
remission prior to allogeneic transplantation.
Reduced intensity conditioning preparative regimens are
recommended to reduce the side effects that go along with ablative preparative regimens.
For more information contact us for
Transplant Creations' clinical research programs are designed according to these