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Stem Cell Transplantation for Cancer

This section informs in general about blood and marrow (stem) cell transplantation for bone marrow and blood cell cancer and organ cancer.


Which types of cancer can be treated by transplantation?
Several types of cancer can be treated by blood and marrow (stem) cell transplantation. The include among others: 

Blood cell cancer Organ cell cancer
  • Acute myelogenous leukemia (AML)
  • Acute lymphoblastic/lymphocytic leukemia (ALL)
  • Chronic myelogenous leukemia (CML)
  • Chronic lymphocytic leukemia (CLL)
  • Multiple Myeloma
  • Myelodysplastic syndrome
  • Breast cancer
  • Ovarian cancer
  • Testicular cancer
  • Kidney cancer
  • Childhood cancers
Lymph node cancer Embryonic neural cell cancer
  • Non-Hodgkin Lymphoma
  • Hodgkin's disease
  • Neuroblastoma

Which effect does transplantation have on cancer?
The goal of treatment for cancer is to kill cancer cells and eradicate the disease. Treatments for cancer should try to achieve that goal. Two mechanisms appear to be very effective when applied to destroy cancer cells receptive for these mechanisms:
                        Chemotherapy
                       
Immune therapy
Stem cell transplantation offers the opportunity to utilize both mechanisms effectively by integration of the mechanisms in one treatment strategy. Chemotherapy is cytotoxic; this means that chemotherapy interferes with cancer cell proliferation and induces cancer cell death. Immune therapy is the overall term for a variety of treatments that elicit an effect mediated by the immune system. Immune competent cells (lymphocytes) are one of the components of the immune system. They have the capability to attack abnormal cells, such as foreign cells and cancer cells. Lymphocytes are among the white blood cells collected during a bone marrow harvest or leukapheresis. They attack cancer cells after allogeneic transplantation and contribute substantially to eradication of cancer cells. Logical combination of these therapy mechanisms provides a powerful treatment option with curative potential. Transplant Creations' clinical research program is designed according to such principle.

 
Which treatment is recommended?
The general principle is to achieve complete remission and to administer an allogeneic transplant in complete remission to induce the curative immune response. 
Treatment modalities used to achieve complete remission include combination chemotherapy and autologous transplantation. The risk of disease recurrence is much higher if the disease is not in complete remission prior to allogeneic transplantation.
Reduced intensity conditioning preparative regimens are recommended to reduce the side effects that go along with ablative preparative regimens. 
For more information contact us for official education.

Transplant Creations' clinical research programs are designed according to these principles.

  • Presentation Clinical Research Program (ppt;pdf)

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